I kēia manawa, ua ʻae ʻia ka neotame e ʻoi aku ma mua o 100 mau ʻāina no ka hoʻohana ʻana ma mua o 1000 mau ʻano huahana.
He kūpono ia no ka hoʻohana ʻana i nā mea inu momona carbonated, yogurts, keke, inu pauka, ʻāʻī pulu ma waena o nā meaʻai ʻē aʻe.Hiki ke hoʻohana ʻia e like me ka mea ʻono ma luna o ka papaʻaina no nā mea inu wela e like me ke kofe.Uhi ia i na ono awaawa .
Hoʻopili ʻo HuaSweet neotame me ka pae aupuni Kina GB29944 a hoʻokō pono i nā kikoʻī FCCVIII, USP, JECFA a me EP.Ua hoʻokumu ʻo HuaSweet i ka ʻoihana kūʻai aku ma luna o kanawalu mau ʻāina ma Asia Hema, ʻEulopa, ʻAmelika Hema, ʻAmelika ʻAmelika a me ʻApelika.
I ka makahiki 2002, ua ʻae ʻo FDA iā ia ma ke ʻano he mea ʻono meaʻai ʻole a hoʻonui i ka ʻono i loko o ʻAmelika Hui Pū ʻIa i nā meaʻai maʻamau, koe wale nō ka ʻiʻo a me ka moa.[3]Ma 2010, ua ʻae ʻia no ka hoʻohana ʻana i nā meaʻai i loko o EU me ka helu E E961.[5]Ua ʻae ʻia ma ke ʻano he mea hoʻohui i nā ʻāina ʻē aʻe ma waho o US a me EU.
Ma US a me EU, ʻo ka lawe ʻana i kēlā me kēia lā (ADI) o ka neotame no nā kānaka he 0.3 a me 2 mg i kēlā me kēia kg o ke kaumaha kino (mg/kg bw), kēlā me kēia.ʻO NOAEL no nā kānaka he 200 mg/kg bw i kēlā me kēia lā i loko o EU.
ʻO nā meaʻai i manaʻo ʻia i kēlā me kēia lā ma lalo o nā pae ADI.Hiki ke hana i ka neotame i loko o ka phenylalanine, akā i ka hoʻohana maʻamau o ka neotame, ʻaʻole ia he mea nui i ka poʻe me ka phenylketonuria.ʻAʻohe hopena maikaʻi ʻole i ka maʻi diabetes type 2.ʻAʻole i manaʻo ʻia he carcinogenic a mutagenic paha.
Hoʻonohonoho ka Center for Science in the Public Interest i ka neotame i palekana.